Yuan Wei-Jie, Ge Jie, Chen Zhi-Kang, Wu Shao-Bin, Shen Hong, Yang Pu, Hu Bin, Zhang Ge-Wen, Chen Zi-Hua
Department of General Surgery, Xiangya Hospital, Central South University, Xiangya Road, Changsha, 410008 Hunan Province, People's Republic of China.
Dig Dis Sci. 2009 Nov;54(11):2410-7. doi: 10.1007/s10620-008-0649-4. Epub 2008 Dec 20.
This study aims to investigate the expression and significance of EphA2 and EphrinA-1 in human gastric adenocarcinoma progression and prognosis. The expression of EphA2 and EphrinA-1 was detected in the cell lines and tissues of gastric adenocarcinoma. Different expression levels of EphA2 and EphrinA-1 were found in two cell lines. The expression of EphA2 and EphrinA-1 was significantly higher in gastric adenocarcinoma tissues than in normal tissues. Statistical analysis showed a significant correlation of EphA2 expression with the depth of tumor invasion, tumor-node-metastasis (TNM) stages, and lymph node metastasis. EphrinA-1 over-expression was significantly correlated with TNM stages and lymph node metastasis, while EphA2 expression was found to be an independent prognostic factor of postoperative gastric adenocarcinoma. In conclusion, the increased expression of EphA2 and EphrinA-1 plays an important role in the progression of human gastric adenocarcinoma, in which elevated EphA2 expression is an independent factor that indicates poor prognosis in postoperative gastric adenocarcinoma.
本研究旨在探讨EphA2和EphrinA-1在人胃腺癌进展及预后中的表达情况及意义。检测了胃腺癌细胞系和组织中EphA2和EphrinA-1的表达。在两种细胞系中发现EphA2和EphrinA-1的表达水平不同。胃腺癌组织中EphA2和EphrinA-1的表达明显高于正常组织。统计分析表明，EphA2表达与肿瘤浸润深度、肿瘤-淋巴结-转移（TNM）分期及淋巴结转移显著相关。EphrinA-1过表达与TNM分期及淋巴结转移显著相关，而EphA2表达是胃腺癌术后的独立预后因素。总之，EphA2和EphrinA-1表达增加在人胃腺癌进展中起重要作用，其中EphA2表达升高是胃腺癌术后预后不良的独立指标。
