Diallo M, Niang S O, Kane A, Dieng M T, Ndiaye B
Service de Dermatologie Hôpital Aristide LeDantec, Dakar, Sénégal.
Dakar Med. 2007;52(1):41-5.
Our aim was to report the cutaneous features of antiphospholipid antibodies syndrome in Dermatology in Dakar.
Our study was retrospective from January 2000 to December 2001. All patients were diagnosed according to the criteria of the international consensus statement in 1999 on the antiphospholipid antibodies.
Eleven cases (all female) were collected with a median age of 28 years. A systemic lupus was associated in 7 cases, a scleroderma in 1 case and mix connectivity in 1 case. The dermatological manifestations found in all patients were necrosis of the extremities (4 cases), purpuric lesions (4), cutaneous ulcers (3), acrocyanosis (2), livedo (1) and subungual splinter hemorrhage (1). The obstetrical incidents were noted in 82% of cases; there were precocious and repeated abortions (in 5 cases), foetal loss (in 4 patients), precocious delivery (in 2 cases), lateness of growth in uterus (in 1 case). It was an arterial thrombosis in 2 cases. The mean level of anticardiolipin antibodies was 60 UGPL and a dissociation of the syphilitic serology was present in 9 patients. A severe thrombopenia in 1 case was observed. The evolution was favorable in 7 patients. In other cases, we noted foetal loss in 2 cases and distal necrosis relapse in 2 cases.
Cutaneous manifestations are diverse. They can be lupus involvements or microcirculatory thrombosis and they make the diagnostic easy.
我们的目的是报告达喀尔皮肤科抗磷脂抗体综合征的皮肤特征。
我们的研究是对2000年1月至2001年12月期间的病例进行回顾性研究。所有患者均根据1999年关于抗磷脂抗体的国际共识声明标准进行诊断。
共收集到11例患者（均为女性），中位年龄为28岁。其中7例合并系统性红斑狼疮，1例合并硬皮病，1例合并混合性结缔组织病。所有患者出现的皮肤表现为肢体坏死（4例）、紫癜性病变（4例）、皮肤溃疡（3例）、肢端发绀（2例）、网状青斑（1例）和甲下裂片形出血（1例）。82%的病例出现产科并发症；包括早产和反复流产（5例）、胎儿丢失（4例）、早产（2例）、子宫内生长迟缓（1例）。2例出现动脉血栓形成。抗心磷脂抗体平均水平为60 UGPL，9例患者梅毒血清学检查结果呈假阳性。观察到1例严重血小板减少症。7例患者病情好转。其他病例中，2例出现胎儿丢失，2例远端坏死复发。
皮肤表现多样。可为狼疮累及或微循环血栓形成，有助于诊断。
