• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一名患有系统性硬化症的男性患者中，与抗磷脂综合征相关的难治性重度指端缺血。

Treatment resistant severe digital ischemia associated with antiphospholipid syndrome in a male patient with systemic sclerosis.

作者信息

Küçükşahin Orhan, Ateş Aşkın, Okoh Alexis K, Kulahcioglu Emre, Turgay Murat, Kınıklı Gülay

机构信息

Department of Rheumatology, Ankara University Medical Faculty, Sihhiye, 06410 Ankara, Turkey.

Department of Internal Medicine, Ankara University Medical Faculty, Sihhiye, 06410 Ankara, Turkey.

出版信息

Case Rep Rheumatol. 2014;2014:291382. doi: 10.1155/2014/291382. Epub 2014 Jul 8.

DOI:10.1155/2014/291382
PMID:25110600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4119641/
Abstract

We report the case of a male patient with limited cutaneous systemic sclerosis (SSc) that was complicated with severe digital ischemia, resistant to medical treatment. Due to the lack of treatment response, further laboratory and imaging studies were conducted. Findings were compatible with antiphospholipid syndrome and oral warfarin was added to the treatment regimen. After successful anticoagulation no further recurrences of digital ischemia were seen. An underlying etiology in SSc patients with treatment resistant digital ischemic necrosis should be suspected for accompanying antiphospholipid syndrome (APS).

摘要

我们报告了一例男性局限性皮肤型系统性硬化症（SSc）患者，该患者并发严重指端缺血，药物治疗无效。由于治疗无反应，遂进行了进一步的实验室和影像学检查。检查结果符合抗磷脂综合征，于是在治疗方案中加入了口服华法林。成功抗凝后，未再出现指端缺血复发情况。对于治疗抵抗性指端缺血性坏死的SSc患者，应怀疑是否并发抗磷脂综合征（APS）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d347/4119641/a8d4a30310d9/CRIRH2014-291382.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d347/4119641/ea879197584c/CRIRH2014-291382.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d347/4119641/a8d4a30310d9/CRIRH2014-291382.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d347/4119641/ea879197584c/CRIRH2014-291382.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d347/4119641/a8d4a30310d9/CRIRH2014-291382.002.jpg

相似文献

1
Treatment resistant severe digital ischemia associated with antiphospholipid syndrome in a male patient with systemic sclerosis.一名患有系统性硬化症的男性患者中，与抗磷脂综合征相关的难治性重度指端缺血。
Case Rep Rheumatol. 2014;2014:291382. doi: 10.1155/2014/291382. Epub 2014 Jul 8.
2
Anti-phospholipid syndrome leading to digital ischaemia and rare organ complications in systemic sclerosis and related disorders.抗磷脂综合征导致系统性硬化症及相关疾病的手指缺血和罕见器官并发症。
Clin Rheumatol. 2021 Jun;40(6):2457-2465. doi: 10.1007/s10067-020-05399-4. Epub 2020 Sep 21.
3
A novel overlap syndrome: systemic sclerosis associated with antiphospholipid syndrome--a case series.一种新型重叠综合征：系统性硬化症合并抗磷脂综合征——病例系列
Ann N Y Acad Sci. 2007 Jun;1108:497-504. doi: 10.1196/annals.1422.053.
4
Extensive abdominal wall ulceration as a late manifestation of antiphospholipid syndrome: a case report.广泛腹壁溃疡作为抗磷脂综合征的晚期表现：一例报告
J Med Case Rep. 2018 Aug 14;12(1):226. doi: 10.1186/s13256-018-1753-5.
5
A Difficult and Rare Case of Warfarin Refractory Antiphospholipid Syndrome Presenting With Catastrophic Antiphospholipid Syndrome Complicated by Gastrointestinal Bleeding.1例华法林难治性抗磷脂综合征伴灾难性抗磷脂综合征并胃肠道出血的疑难罕见病例
Cureus. 2021 Aug 11;13(8):e17106. doi: 10.7759/cureus.17106. eCollection 2021 Aug.
6
Antiphospholipid syndrome associated with progressive systemic sclerosis.抗磷脂综合征与进行性系统性硬化症相关。
J Dermatol. 1996 May;23(5):347-51. doi: 10.1111/j.1346-8138.1996.tb04029.x.
7
Toe necrosis and acute myocardial infarction precipitated by a pheochromocytoma in a patient with systemic sclerosis.系统性硬化症患者因嗜铬细胞瘤引发的足趾坏死和急性心肌梗死
J Clin Rheumatol. 2007 Dec;13(6):331-3. doi: 10.1097/RHU.0b013e31815c1df8.
8
Antiphospholipid syndrome (APS) revisited: Would migraine headaches be included in future classification criteria?抗磷脂综合征（APS）再探讨：偏头痛是否会被纳入未来的分类标准？
Immunol Res. 2017 Feb;65(1):230-241. doi: 10.1007/s12026-016-8831-9.
9
Can neurologic manifestations of Hughes (antiphospholipid) syndrome be distinguished from multiple sclerosis? Analysis of 27 patients and review of the literature.休斯（抗磷脂）综合征的神经系统表现能与多发性硬化症区分开吗？27例患者的分析及文献综述。
Medicine (Baltimore). 2000 Jan;79(1):57-68. doi: 10.1097/00005792-200001000-00006.
10
Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome.抗磷脂综合征缺血性脑卒中患者二级预防中单联抗血小板与双联抗血小板抗凝治疗的比较。
Int J Med Sci. 2009 Dec 5;7(1):15-8. doi: 10.7150/ijms.7.15.

引用本文的文献

1
Antiphospholipid Syndrome - A Case Report of Pulmonary Thromboembolism, Followed with Acute Myocardial Infarction in Patient with Systemic Sclerosis.抗磷脂综合征——系统性硬化症患者发生肺血栓栓塞后并发急性心肌梗死的病例报告
Open Access Maced J Med Sci. 2015 Dec 15;3(4):705-9. doi: 10.3889/oamjms.2015.114. Epub 2015 Nov 8.

本文引用的文献

1
Clinical significance of antiphospholipid antibodies in Indian scleroderma patients.抗磷脂抗体在印度硬皮病患者中的临床意义。
Rheumatol Int. 2009 Dec;30(2):277-9. doi: 10.1007/s00296-009-1107-0.
2
Low-dose combination therapy of severe digital ulcers in diffuse progressive systemic sclerosis with the endothelin-1 receptor antagonist bosentan and the phosphodiesterase V inhibitor sildenafil.内皮素-1受体拮抗剂波生坦与磷酸二酯酶V抑制剂西地那非联合低剂量治疗弥漫性进行性系统性硬化症严重指端溃疡
J Dtsch Dermatol Ges. 2009 Oct;7(10):888-91. doi: 10.1111/j.1610-0387.2009.07057.x.
3
[Antiphospholipid antibodies syndrome in dermatology in Dakar: 11 case report].
[达喀尔皮肤科抗磷脂抗体综合征：11例报告]
Dakar Med. 2007;52(1):41-5.
4
A novel overlap syndrome: systemic sclerosis associated with antiphospholipid syndrome--a case series.一种新型重叠综合征：系统性硬化症合并抗磷脂综合征——病例系列
Ann N Y Acad Sci. 2007 Jun;1108:497-504. doi: 10.1196/annals.1422.053.
5
Successful treatment with bosentan for severe digital ischaemia in limited cutaneous systemic sclerosis.波生坦成功治疗局限性皮肤型系统性硬化症所致严重手指缺血。
Ann Rheum Dis. 2007 Aug;66(8):1122-3. doi: 10.1136/ard.2006.057604.
6
Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients.抗磷脂综合征：1000例患者队列中的临床和免疫学表现及疾病表达模式
Arthritis Rheum. 2002 Apr;46(4):1019-27. doi: 10.1002/art.10187.
7
Acute interstitial pneumonia associated with antiphospholipid syndrome in a patient with systemic sclerosis.系统性硬化症患者并发抗磷脂综合征相关的急性间质性肺炎。
Clin Exp Rheumatol. 2000 Nov-Dec;18(6):786.
8
Antiphospholipid syndrome associated with progressive systemic sclerosis.抗磷脂综合征与进行性系统性硬化症相关。
J Dermatol. 1996 May;23(5):347-51. doi: 10.1111/j.1346-8138.1996.tb04029.x.
9
Antiphospholipid syndrome in scleroderma.硬皮病中的抗磷脂综合征
J Rheumatol. 1993 Sep;20(9):1598-600.
10
Clinical significance of anticardiolipin antibodies in patients with systemic sclerosis.抗心磷脂抗体在系统性硬化症患者中的临床意义
Autoimmunity. 1995;20(1):1-7. doi: 10.3109/08916939508993333.