Kawasaki Naruo, Suzuki Yutaka, Urashima Mitsuyoshi, Nakayoshi Tomoko, Tsuboi Kazuto, Tanishima Yuichiro, Hanyu Nobuyoshi, Kashiwagi Hideyuki
Department of Surgery, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan.
Hepatogastroenterology. 2008 Sep-Oct;55(86-87):1843-5.
BACKGROUND/AIMS: For gastrointestinal functional analysis such as gastric emptying tests, either a liquid or solid meal is used as a test meal. Only a few studies have compared meal characteristics, such as liquid and solid. No previous study has compared test meals that had the same composition but different properties. The aim of this study was to compare the gastric emptying and absorption obtained by 13C-breath test after ingestion of liquid or gelatinized liquid nutrients.
Ten healthy volunteers were studied four times, with 2-week intervals. For the test meal, 200 mL of liquid meals (200 kcal) and gelatinized liquid meals were used. Gelatinized liquid nutrients were prepared by mixing 6 g, 12 g and 18 g of Natural psyllium husk with 200 mL of liquid meals. Breath samples were collected for four hours. Gastric emptying were expressed as the time of peak excretion, absorption were expressed as the area under the 13CO2 curve up to the time of peak excretion.
Gastric emptying times were 54.5, 54.5, 81.7 and 93.3 min. Absorption was 20.8, 20.9, 27.8 and 29.8% dose.
Gelatinization influences gastric emptying, but does not influence absorption. Gelatinized liquid meals may be useful for a substitute for solid meals on gastrointestinal functional analysis.
背景/目的：在进行诸如胃排空试验等胃肠功能分析时，液体或固体餐食都可作为试验餐。仅有少数研究比较了餐食特性，如液体和固体餐食。此前尚无研究比较过成分相同但性质不同的试验餐。本研究的目的是比较摄入液体或糊化液体营养物后通过13C呼气试验测得的胃排空和吸收情况。
对10名健康志愿者进行了4次研究，间隔为2周。试验餐采用200毫升液体餐（200千卡）和糊化液体餐。糊化液体营养物是通过将6克、12克和18克天然车前子壳与200毫升液体餐混合制备而成。采集4小时的呼气样本。胃排空以排泄峰值时间表示，吸收以排泄峰值时间前13CO2曲线下的面积表示。
胃排空时间分别为54.5、54.5、81.7和93.3分钟。吸收量分别为剂量的20.8%、20.9%、27.8%和29.8%。
糊化作用影响胃排空，但不影响吸收。糊化液体餐在胃肠功能分析中可作为固体餐的替代品。
