设定结直肠癌KRAS检测的未来标准。 - Suppr

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超能文献

Setting future standards for KRAS testing in colorectal cancer.

作者信息

van Krieken Han, Tol Jolien

出版信息

Pharmacogenomics. 2009 Jan;10(1):1-3. doi: 10.2217/14622416.10.1.1.

DOI:10.2217/14622416.10.1.1

PMID:19102707

Abstract

摘要

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Optimization of routine KRAS mutation PCR-based testing procedure for rational individualized first-line-targeted therapy selection in metastatic colorectal cancer.优化常规 KRAS 基因突变聚合酶链反应检测程序，以合理选择转移性结直肠癌的一线靶向个体化治疗。

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Comparison of COBAS 4800 KRAS, TaqMan PCR and high resolution melting PCR assays for the detection of KRAS somatic mutations in formalin-fixed paraffin embedded colorectal carcinomas.比较 COBAS 4800 KRAS、TaqMan PCR 和高分辨率熔解 PCR 检测方法在福尔马林固定石蜡包埋结直肠癌中检测 KRAS 体细胞突变的性能。

Virchows Arch. 2013 Mar;462(3):329-35. doi: 10.1007/s00428-013-1380-x. Epub 2013 Feb 12.

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Analytical performance of a PCR assay for the detection of KRAS mutations (codons 12/13 and 61) in formalin-fixed paraffin-embedded tissue samples of colorectal carcinoma.用于检测结直肠癌福尔马林固定石蜡包埋组织样本中 KRAS 突变（密码子 12/13 和 61）的 PCR 检测分析性能。

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Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours - implications for personalised cancer medicine.散发性结直肠肿瘤中“热点”密码子以外的 K-Ras 突变的激活——对个体化癌症治疗的影响。

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