Gkika Dimitra, Prevarskaya Natalia
Inserm U800, Equipe labellisée par la Ligue Nationale Contre le Cancer, F59656 Villeneuve d'Ascq, France.
Biochim Biophys Acta. 2009 Jun;1793(6):953-8. doi: 10.1016/j.bbamcr.2008.11.010. Epub 2008 Dec 6.
Transient Receptor Potential (TRP) channels modulate intracellular Ca2+ concentrations, consequently affecting both cell death and proliferation. It is not, therefore, surprising that the membrane expression of some TRP channels is altered during tumor growth and metastasis. These variations in channel abundance are due to TRP regulation on the transcriptional, translational, and targeting levels. This article mainly reviews the transcriptional mechanisms modulating TRP expression during tumorigenesis, involving hormones, growth factors, and alternative splicing.
瞬时受体电位（TRP）通道可调节细胞内钙离子浓度，进而影响细胞死亡和增殖。因此，在肿瘤生长和转移过程中某些TRP通道的膜表达发生改变也就不足为奇了。通道丰度的这些变化归因于TRP在转录、翻译和靶向水平上的调控。本文主要综述肿瘤发生过程中调节TRP表达的转录机制，涉及激素、生长因子和可变剪接。
