[胃腺癌中的爱泼斯坦-巴尔病毒感染与p16（INK4a）过表达]

[Epstein-Barr virus infection and p16(INK4a) overexpression in gastric adenocarcinoma].

作者信息

Wang Ping, Zhang Qing, Yang Jin-Feng, Cheng Ze-Nong, Zhang Ke, Yu Dong-Hong

机构信息

Anhui Key Laboratory of Infection and Immunology, Department of Pathology, Bengbu Medical College, Anhui 233003, China.

出版信息

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008 Aug;22(4):244-6.

PMID:19105332

Abstract

OBJECTIVE

To study Epstein-Barr virus infection and p16 protein abnormal expresson in carcinogenesis and progression of gastric adenocarcinomas (GAC).

METHODS

Immunohistochemical staining SP method was used to detect the expression of LMP-1 and p16 in 97 cases of GAC.

RESULTS

EBV LMP-1 and p16 protein were detected in 30.9% (30/97) and in 63.91% (62/97) cases of gastric adenocarcinomas respectively. There was no significant difference between EBV-positive and EBV-negative gastric carcinomas in sex, histologic type, depth of tumor invision, lymph node metastasis and clinical stages (P > 0.05); overexpression of p16 was associated with lymph node metastasis and clinical stages; no correlation was found between the expression of EBV LMP-1 and p16 protein.

CONCLUSION

EBV play a role in carcinogensis of GAC. 2. P16 gene abnormality is frequently involved in GAC and might be one of the important prognostic factors. 3. EBV infection and p16 alteration are two independent roles in GAC carcinogenesis.

摘要

目的

研究爱泼斯坦-巴尔病毒感染及p16蛋白异常表达在胃腺癌发生发展中的作用。

方法

采用免疫组织化学染色SP法检测97例胃腺癌中LMP-1和p16的表达。

结果

EBV LMP-1和p16蛋白在胃腺癌中的检出率分别为30.9%（30/97）和63.91%（62/97）。EBV阳性与阴性胃癌在性别、组织学类型、肿瘤浸润深度、淋巴结转移及临床分期方面差异无统计学意义（P>0.05）；p16过表达与淋巴结转移及临床分期相关；EBV LMP-1与p16蛋白表达无相关性。