Ojima Hitoshi, Saito Kana, Yamauchi Hayato, Yamaki Ei, Idetu Akihito, Hosouchi Yasuo, Nishida Yasuji, Tukada Katuhiko, Kato Hiroyuki, Kuwano Hiroyuki
Department of Surgery, Gunma Prefecture Saiseikai-Maebashi Hospital, 564-1 Kami-shinden, Maebashi, Gunma 371-0821, Japan.
Anticancer Res. 2006 Mar-Apr;26(2A):933-7.
The Epstein-Barr virus (EBV) has been detected in lymphoepithelioma of the nasopharynx and lymphoepithelioma-like carcinomas in various organs. Ten percent of gastric carcinomas, including lymphepithelioma-like carcinoma and adenocarcinoma, are associated with EBV infection. The p16 protein is a cyclin-dependent kinase (CDK) inhibitor that decelerates the cell cycle, inactivating the CDKs that phosphorylate retinoblastoma (Rb) protein.
To clarify the relationship between p16 overexpression and EBV-associated gastric carcinomas, immunohistochemical analysis of p16 and detection of EBV by in situ hybridization were performed on 238 formalin-fixed and paraffin-embedded samples of gastric carcinomas.
The non-expression of p16 protein in EBV-positive and -negative carcinoma was 81.5% (53 out of 65 samples) and 26.6% (46 out of 173 samples), respectively (p < 0.001).
We suggest that the carcinogenesis of EBV-associated gastric cancers may be closely associated with a p16 abnormality.
在鼻咽癌的淋巴上皮瘤以及各器官的淋巴上皮瘤样癌中已检测到爱泼斯坦-巴尔病毒（EBV）。包括淋巴上皮瘤样癌和腺癌在内的10%的胃癌与EBV感染相关。p16蛋白是一种细胞周期蛋白依赖性激酶（CDK）抑制剂，可使细胞周期减速，使磷酸化视网膜母细胞瘤（Rb）蛋白的CDK失活。
为阐明p16过表达与EBV相关胃癌之间的关系，对238例福尔马林固定石蜡包埋的胃癌样本进行了p16的免疫组化分析和EBV的原位杂交检测。
EBV阳性和阴性癌中p16蛋白的无表达率分别为81.5%（65个样本中的53个）和26.6%（173个样本中的46个）（p<0.001）。
我们认为EBV相关胃癌的致癌作用可能与p16异常密切相关。
