Hashemi-Soteh Mohammad Bagher, Nejad Ali Vali, Ataei Golamreza, Tafazoli Alireza, Ghasemi Dariush, Siamy Rita
Immunogenetic Research Center, Molecular and Cell Biology Research Center, Medical Faculty, Mazandaran University of Medical Sciences SariMazandaran Iran.
Ghaemshahr Health Center, Mazandaran University of Medical Sciences Mazandaran Iran.
Int J Reprod Biomed. 2019 Sep 3;17(8):543-550. doi: 10.18502/ijrm.v17i8.4819. eCollection 2019 Aug.
Genetic testing has been widely introduced for many hereditary disorders. While the attitudes towards these facilities have been evaluated in many countries, there are only a few reports on the knowledge of and the orientation among Iranians.
The current study assesses the attitudes and knowledge of pre-marriage individuals toward the availability and use of genetic tests.
A comprehensive questionnaire was distributed among 408 marrying individuals. The questions addressed the demographic characteristics along the registration of participant's knowledge, education, and attitude toward genetic testing. The individuals were divided into three groups based on their knowledge: 1) Scored above 80 to 100 were defined as "good" 2) 60 to 80 as "average" 3) less than 60 as "poor" knowledge.
Most participants (86%) believed consanguineous marriages increase the risk of genetic diseases; 82.3% knew that thalassemia is a type of genetic disease, only 33.3% could distinguish prenatal diagnosis (PND) from other laboratory tests. The relationship between the participants' knowledge and their level of education was significant (r░=░0.78, p░<░0.001), age (r= -0.16, p░<░0.01), and urbanity (p░<░0.01). A prominent relationship was observed between the knowledge (r░=░0.64, p░<░0.001) or education (r░=░0.62, p░<░0.001) and people's desire to use the genetic tests before the wedding ceremony. No significant correlations were found between the participant's attitude and their ages/urbanity. Most of the individuals agreed to arrange a genetic counseling before marriage (0.94%).
This study revealed that most individuals were interested in using genetic counseling services and genetic tests before marriage.
基因检测已被广泛应用于多种遗传性疾病。虽然许多国家已对人们对这些检测设施的态度进行了评估，但关于伊朗人对基因检测的了解情况和认知倾向的报告却很少。
本研究评估婚前人群对基因检测可用性和使用情况的态度及知识水平。
向408名即将结婚的个体发放了一份综合问卷。问题涉及人口统计学特征以及参与者对基因检测的知识、教育程度和态度。根据知识水平将个体分为三组：1）得分在80至100分之间的定义为“良好”；2）60至80分的为“中等”；3）低于60分的为“较差”。
大多数参与者（86%）认为近亲结婚会增加患遗传病的风险；82.3%的人知道地中海贫血是一种遗传病，只有33.3%的人能区分产前诊断（PND）与其他实验室检查。参与者的知识水平与教育程度（r = 0.78，p < 0.001）、年龄（r = -0.16，p < 0.01）和是否为城市居民（p < 0.01）之间存在显著关系。在知识水平（r = 0.64，p < 0.001）或教育程度（r = 0.62，p < 0.001）与人们在婚礼前进行基因检测的意愿之间观察到显著关系。参与者的态度与年龄/是否为城市居民之间未发现显著相关性。大多数人同意在婚前安排遗传咨询（0.94%）。
本研究表明，大多数人对婚前使用遗传咨询服务和基因检测感兴趣。
