Gillis S
Immunex Research and Development Corporation, Seattle, Washington 98101.
Curr Opin Immunol. 1991 Jun;3(3):315-9. doi: 10.1016/0952-7915(91)90030-5.
The molecular characterization of cytokine receptors has progressed rapidly over the past 5 years as a result of availability of radiolabeled cytokines, as well as the identification or creation of cell lines that express significant numbers of receptors at the cell surface. This explosion in research effort has led to establishment of multiple cytokine-receptor gene families and the realization that inhibition of cytokine function at the level of ligand-receptor interaction may be an important area for therapeutic drug development.
由于放射性标记细胞因子的可得性，以及对在细胞表面表达大量受体的细胞系的鉴定或创建，细胞因子受体的分子特征在过去5年里取得了迅速进展。这项研究工作的激增导致了多个细胞因子受体基因家族的建立，并认识到在配体-受体相互作用水平上抑制细胞因子功能可能是治疗药物开发的一个重要领域。
