Xie Zong-Ping, Zhang Chang-Qing, Yi Cheng-Qing, Qiu Jian-Jun, Wang Jian-Qiang, Zhou Juan
Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Jiaotong University, Shanghai, China.
J Biomed Mater Res B Appl Biomater. 2009 Jul;90(1):195-201. doi: 10.1002/jbm.b.31273.
There are many in vitro experiments showing that particulate bioactive glasses have a broad and certain antibacterial effect, but there is no report about this antibacterial effect in vivo so far. The aim of this study is to examine the efficacy of particulate Bioglass in reducing the rate of infection with Staphylococcus aureus after the fixation of open tibial fractures in rabbits. The test in vivo was carried out with male rabbits split into two groups infected with Staphylococcus aureus at the right tibial fracture sites fixed with plate and screw, either with or without bioactive glass respectively. Culture results show that six of ten rabbits from the control group had a positive culture for the strain of Staphylococcus aureus ATCC25923, compared with six of the nine rabbits from the Bioglass group. The median radiographic score is 4.5 points for the rabbits from the control group and 4 points for the rabbits from the Bioglass group. The median histopathological score was 2.5 points for the rabbits in the control group and 3 points for the rabbits in the Bioglass group. In conclusion, this study showed no significant difference between the rates of infection of two groups. Particulate Bioglass did not reduce the rate of infection with Staphylococcus aureus after the fixation of open tibial fractures in rabbits.
有许多体外实验表明，颗粒状生物活性玻璃具有广泛且一定的抗菌作用，但目前尚无关于其体内抗菌作用的报道。本研究的目的是检验颗粒状生物活性玻璃在兔开放性胫骨骨折固定后降低金黄色葡萄球菌感染率的效果。体内试验以雄性兔进行，分为两组，分别在右侧胫骨骨折部位用钢板和螺钉固定，一组不使用生物活性玻璃，另一组使用生物活性玻璃，均感染金黄色葡萄球菌。培养结果显示，对照组10只兔中有6只金黄色葡萄球菌ATCC25923菌株培养呈阳性，生物活性玻璃组9只兔中有6只培养呈阳性。对照组兔的放射学评分中位数为4.5分，生物活性玻璃组兔为4分。对照组兔的组织病理学评分中位数为2.5分，生物活性玻璃组兔为3分。总之，本研究表明两组感染率之间无显著差异。颗粒状生物活性玻璃在兔开放性胫骨骨折固定后并未降低金黄色葡萄球菌的感染率。
