Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran.
J Mater Sci Mater Med. 2021 Mar 12;32(3):29. doi: 10.1007/s10856-021-06496-9.
Bioactive glasses have attracted enormous attention in the field of biomaterials for dental and medical applications. Incorporation of antibacterial ions within BGs has been proved to be a promising approach to fortify their bactericidal character. In this study, homogenous BGs containing silver (Ag) ions were synthesized by sol-gel method. Subsequently, the presence of the embedded ions were characterized by X-ray fluorescence (XRF) elemental analysis and energy dispersive X-ray (EDX) spectroscopy. Moreover, released ions were measured in simulated body fluid (SBF) and their antibacterial effectiveness was further verified using minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC) tests. A crystalline hydroxyapatite layer was formed on the Ag-BG surfaces at day 5 approved by X-ray diffraction indicating the preserved bioactivity. The resultant uniform, mono-dispersed and dense nanoparticles show 19 great potential for a range of orthopedic and dental applications.
生物活性玻璃在牙科和医学应用领域的生物材料领域引起了极大的关注。在 BGs 中掺入抗菌离子已被证明是增强其杀菌特性的一种有前途的方法。在这项研究中，通过溶胶-凝胶法合成了含有银（Ag）离子的均匀 BGs。随后，通过 X 射线荧光（XRF）元素分析和能谱（EDX）光谱对嵌入离子的存在进行了表征。此外，在模拟体液（SBF）中测量了释放的离子，并通过最小杀菌浓度（MBC）和最小抑菌浓度（MIC）试验进一步验证了其抗菌效果。X 射线衍射表明，在第 5 天，Ag-BG 表面形成了结晶羟基磷灰石层，证明了其生物活性得以保留。所得的均匀、单分散且致密的纳米颗粒显示出在骨科和牙科应用方面有 19 种巨大的潜力。
