患有系统性红斑狼疮的黑人中的Gm同种异型

Gm allotypes in blacks with systemic lupus erythematosus.

作者信息

Fedrick J A, Pandey J P, Chen Z, Fudenberg H H, Ainsworth S K, Dobson R L

出版信息

Hum Immunol. 1983 Oct;8(2):177-81. doi: 10.1016/0198-8859(83)90012-5.

Abstract

Serum samples were collected from 328 healthy American Blacks and from 61 American Blacks with systemic lupus erythematosus (SLE). Sera were typed for the Gm1,2,3,5,6,13,17, and 21 allotypes as well as for the Km(1) allotype. The frequency of Gm phenotype 1,17;5,6,13 was significantly increased in the SLE patients (p = 0.0001, RR = 3.19, EF = 0.29). Our data suggest the existence of at least two immunoglobulin allotype associated genes that somehow interact to increase susceptibility to SLE in Blacks. To our knowledge, this is the first report of an association of Gm and SLE in Blacks.

摘要

从328名健康美国黑人以及61名患有系统性红斑狼疮（SLE）的美国黑人中采集血清样本。对血清进行Gm1、2、3、5、6、13、17和21同种异型以及Km(1)同种异型分型。在SLE患者中，Gm表型1,17;5,6,13的频率显著增加（p = 0.0001，RR = 3.19，EF = 0.29）。我们的数据表明至少存在两个与免疫球蛋白同种异型相关的基因，它们以某种方式相互作用，增加了黑人患SLE的易感性。据我们所知，这是关于黑人中Gm与SLE关联的首次报告。