疾病关联中的免疫球蛋白同种异型和限制性片段长度多态性
Immunoglobulin allotypes and RFLPs in disease association.
作者信息
Propert D
机构信息
Department of Applied Biology and Biotechnology, Royal Melbourne Institute of Technology, Vic., Australia.
出版信息
Exp Clin Immunogenet. 1995;12(3):198-205. doi: 10.1159/000424872.
PMID:8534506
Abstract
Immunoglobulin heavy chain (Gm) and light chain (Km) allotypes have been extensively studied as possible markers of susceptibility to a range of immune-related diseases including malignancies, infectious diseases and autoimmune disorders. This review is concentrated on susceptibility to multiple sclerosis, systemic lupus erythematosus and insulin-dependent diabetes mellitus.
摘要
免疫球蛋白重链（Gm）和轻链（Km）同种异型已被广泛研究，作为一系列免疫相关疾病（包括恶性肿瘤、传染病和自身免疫性疾病）易感性的可能标志物。本综述集中于多发性硬化症、系统性红斑狼疮和胰岛素依赖型糖尿病的易感性。
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