系统性红斑狼疮中的免疫球蛋白GM和KM同种异型

Immunoglobulin GM and KM allotypes in systemic lupus erythematosus.

作者信息

Pandey J P, Cooper G S, Treadwell E L, Gilkeson G S, St Clair E W, Dooley M A

机构信息

Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425-2230, USA.

出版信息

Exp Clin Immunogenet. 2001;18(3):117-22. doi: 10.1159/000049190.

DOI:10.1159/000049190

PMID:11549840

Abstract

Genetic variation in immunoglobulin gamma (GM) and kappa (KM) chains was associated with systemic lupus erythematosus (SLE) in some studies. However, the data are conflicting, and only one study examined associations in African-Americans. We examined GM and KM allotypes, by race, in a population-based case-control study of SLE. Sera from patients (n = 222) and controls (n = 273) were typed for GM and KM allotypes by a hemagglutination inhibition method. GM phenotypes were not significantly associated with SLE in African-Americans or Caucasians. However, the frequency of KM phenotypes in Caucasian patients was significantly different from that in controls (p = 0.032). KM3,3 was associated with an increased risk, whereas KM1,3 was associated with a lower relative risk of SLE. In African-Americans, however, the pattern of associations with KM phenotypes differed from that in Caucasians, and the overall difference between patients and controls was not statistically significant.

摘要

在一些研究中，免疫球蛋白γ（GM）链和κ（KM）链的基因变异与系统性红斑狼疮（SLE）相关。然而，数据存在冲突，且仅有一项研究调查了非裔美国人中的关联情况。我们在一项基于人群的SLE病例对照研究中，按种族检测了GM和KM的同种异型。通过血凝抑制法对患者（n = 222）和对照（n = 273）的血清进行GM和KM同种异型分型。GM表型在非裔美国人和白种人中与SLE均无显著关联。然而，白种人患者中KM表型的频率与对照相比有显著差异（p = 0.032）。KM3,3与风险增加相关，而KM1,3与SLE的相对风险较低相关。然而，在非裔美国人中，与KM表型的关联模式与白种人不同，患者与对照之间的总体差异无统计学意义。