Li Shuting, Wang Janshi, Zhao Shulin
College of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin, 541004, China.
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 15;877(3):155-8. doi: 10.1016/j.jchromb.2008.11.042. Epub 2008 Dec 6.
A novel capillary electrophoresis (CE) with chemiluminescence (CL) detection method for determination of terbutaline sulfate has been developed. This method is based on the chemiluminescence reaction of potassium ferricyanide with luminol in sodium hydroxide medium sensitized by terbutaline sulfate. With the peak height as a quantitative parameter applying optimum working conditions, terbutaline sulfate is determined over the range of 7.0 x 10(-8) to 3.6 x 10(-6)M with a detection limit of 3.0 x 10(-8)M. The relative standard deviation (RSD) was 4.6% for 6.0 x 10(-7)M terbutaline sulfate (n=11). The proposed method has been applied to determination of terbutaline sulfate in commercial terbutaline sulfate drug and spiked in human urine with satisfactory results.
已开发出一种用于测定硫酸特布他林的新型毛细管电泳（CE）-化学发光（CL）检测方法。该方法基于在氢氧化钠介质中，硫酸特布他林敏化铁氰化钾与鲁米诺的化学发光反应。在最佳工作条件下，以峰高为定量参数，硫酸特布他林的测定范围为7.0×10⁻⁸至3.6×10⁻⁶M，检测限为3.0×10⁻⁸M。对于6.0×10⁻⁷M硫酸特布他林，相对标准偏差（RSD）为4.6%（n = 11）。该方法已应用于市售硫酸特布他林药物及加标人尿中硫酸特布他林的测定，结果令人满意。
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