Chen Chi-Huang, Chen I-Ching, Wang Yu-Chi, Liu Jah-Yao, Wu Gwo-Jang, Tzeng Chii-Ruey
Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taiwan.
Fertil Steril. 2009 Jun;91(6):2732.e5-7. doi: 10.1016/j.fertnstert.2008.10.074. Epub 2008 Dec 24.
To present male gender preselection after successive gestational hyperandrogenism and female pseudohermaphroditism by pregnancy luteomas.
Case report.
University-based teaching hospital.
PATIENT(S): We describe herein a gravida who presented two successive 46, XX disorders of sex development with apparent female genitalia with an enlarged clitoris due to maternal androgen excess from pregnancy luteoma. The maternal hyperandrogenemia returned to a normal level and bilateral luteoma regressed spontaneously postpartum. After gender preselection by Y-bearing spermatozoa for intrauterine insemination at the third gestation, a healthy boy was born in spite of the exaggerated maternal androgen production of pregnancy luteoma to avoid 46, XX disorders of sex development.
INTERVENTION(S): Y-bearing spermatozoa for intrauterine insemination as male gender preselection.
MAIN OUTCOME MEASURE(S): Boy born after gender preselection for intrauterine insemination and cesarean section.
RESULT(S): Healthy boy born without disorder of sex development after antenatal maternal androgen excess of ovarian luteoma.
CONCLUSION(S): Successive pregnancy luteomas associated with maternal hyperandrogenism may cause female disorders of sex development. Male preselection ameliorates the insult of external genitalia ambiguity by antenatal androgen excess in this matter of concern.
介绍妊娠黄体瘤导致连续妊娠期间高雄激素血症及女性假两性畸形后的男性性别选择。
病例报告。
大学附属医院。
本文描述了一名孕妇，其连续两次出现46,XX性发育障碍，外生殖器明显为女性，但阴蒂因妊娠黄体瘤导致母体雄激素过多而增大。母体高雄激素血症在产后恢复正常水平，双侧黄体瘤也自行消退。在第三次妊娠时，通过选择含Y精子进行宫内授精进行性别选择，尽管妊娠黄体瘤使母体雄激素分泌过多，但仍产下一名健康男婴，避免了46,XX性发育障碍。
选择含Y精子进行宫内授精作为男性性别选择。
宫内授精性别选择及剖宫产术后出生的男婴。
产前母体因卵巢黄体瘤出现雄激素过多，但产下的健康男婴未出现性发育障碍。
连续妊娠黄体瘤伴母体高雄激素血症可能导致女性性发育障碍。在此问题上，男性性别选择可改善产前雄激素过多导致的外生殖器模糊不清的问题。
