西伯利亚仓鼠（Phodopus sungorus）自发性乳腺肿瘤的形态学和免疫组织化学研究。

Morphological and immunohistochemical studies of spontaneous mammary tumours in Siberian hamsters (Phodopus sungorus).

作者信息

Kondo H, Onuma M, Shibuya H, Sato T

机构信息

Laboratory of Veterinary Pathology, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan.

出版信息

J Comp Pathol. 2009 Feb-Apr;140(2-3):127-31. doi: 10.1016/j.jcpa.2008.09.012. Epub 2008 Dec 25.

DOI:10.1016/j.jcpa.2008.09.012

PMID:19110261

Abstract

Mammary tumours from 12 domestic Siberian hamsters (11 females, 1 male) were examined. Histopathology revealed three subtypes: simple adenoma, tubulopapillary carcinoma, and complex carcinoma. In five cases of malignant mammary tumour, focal infiltration into the surrounding fibrous connective tissue was present; however, no invasion of either lymphatics or blood vessels was observed. Apocrine secretion from neoplastic luminal epithelial cells was prominent in all tumours. Expression of oestrogen receptor alpha, progesterone receptor, and androgen receptor was evaluated immunohistochemically in neoplastic epithelial cells. Ten of the 12 tumours were positive for androgen receptor and all were negative for progesterone receptor. Five tumours expressed oestrogen receptor alpha.

摘要

对12只家养西伯利亚仓鼠（11只雌性，1只雄性）的乳腺肿瘤进行了检查。组织病理学显示有三种亚型：单纯性腺瘤、管状乳头状癌和复杂癌。在5例恶性乳腺肿瘤中，存在局部浸润至周围纤维结缔组织的情况；然而，未观察到淋巴管或血管侵犯。所有肿瘤中肿瘤性管腔上皮细胞的顶浆分泌都很突出。采用免疫组织化学方法评估了肿瘤上皮细胞中雌激素受体α、孕激素受体和雄激素受体的表达。12个肿瘤中有10个雄激素受体呈阳性，所有肿瘤孕激素受体均为阴性。5个肿瘤表达雌激素受体α。