Effect of afobazole on teratogenic activity of cyclophosphamide in rats.
作者信息
Shreder O V, Smolnikova N M, Durnev A D, Seredenin S B
机构信息
V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2008 Apr;145(4):436-9. doi: 10.1007/s10517-008-0111-9.
PMID:19110587
Abstract
A new anxiolytic afobazole (1-100 mg/kg perorally, Russia) dose-dependently abolished the embryotoxic and teratogenic effects of cyclophosphamide and reduced the range of induced malformations in outbred albino rats. Our results suggest that afobazole possesses antiteratogenic activity.
摘要
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