Wen Sicheng, Moss Steven F
Department of Medicine, Division of Gastroenterology, Rhode Island Hospital and Brown University, 593 Eddy Street, Providence, RI 02903, USA.
Cancer Lett. 2009 Sep 8;282(1):1-8. doi: 10.1016/j.canlet.2008.11.016. Epub 2008 Dec 25.
Helicobacter pylori infection is the most important risk factor in the development of non-cardia gastric adenocarcinoma; host genetic variability and dietary co-factors also modulate risk. Because most H. pylori infections do not cause cancer, H. pylori heterogeneity has been investigated to identify possible virulence factors. The strongest candidates are genes within the cag (cytotoxin-associated antigen) pathogenicity island, including the gene encoding the CagA protein, as well as polymorphic variation in the VacA vacuolating exotoxin and the blood group antigen binding adhesin BabA. Improved understanding of the pathogenesis of H. pylori-associated gastric cancer may improve risk stratification for prevention and therapy.
幽门螺杆菌感染是非贲门胃腺癌发生的最重要风险因素;宿主遗传变异性和饮食协同因素也会调节风险。由于大多数幽门螺杆菌感染不会导致癌症,因此人们对幽门螺杆菌的异质性进行了研究,以确定可能的毒力因子。最有力的候选因素是cag(细胞毒素相关抗原)致病岛中的基因,包括编码CagA蛋白的基因,以及空泡毒素VacA和血型抗原结合黏附素BabA中的多态性变异。对幽门螺杆菌相关胃癌发病机制的深入了解可能会改善预防和治疗的风险分层。