Piérard-Franchimont Claudine, Henry Frédérique, Quatresooz Pascale, Vroome Valérie, Piérard Gérald E
Department of Dermatopathology, University Hospital Sart Tilman, Liège, Belgium.
J Drugs Dermatol. 2008 Sep;7(9):873-8.
Solar lentigines represent a common feature of photoaging, particularly on the back of the hands. Bleaching agents are usually proposed to lighten the shade of the lesions.
The study was randomized and designed to assess the effect of a bleaching solution containing 2% mequinol (4-hydroxyanisole, 4HA) and 0.01% tretinoin (Solagé). The formulation was applied twice daily for 3 months on solar lentigines present on the back of one hand. The lesions on the other hand were treated with the ethyl alcohol vehicle which served as a control. Clinical diagnosis was confirmed using dermoscopy. In addition, objective measurements of the hypermelanosis were performed at 1-month intervals during and after treatment. Clinical assessments were used as well as narrow-band reflectance spectrophotometry, image analysis of video-recorded ultraviolet light-enhanced visualization (ULEV method) and photodensitometry of the corneomelametry test.
The multipronged assessment of the lesional color demonstrated a significant lightening effect of the 4HA/tretinoin solution. This was demonstrated after 2 months of treatment and was maintained at least 2 months after stopping treatment.
Both the visual ratings and the objective bioinstrumental methods indicate the rapid lightening effect of the 4HA/tretinoin formulation. After stopping treatment, the rate of repigmentation appeared to have slowed compared to the depigmentation phase.
日光性雀斑是光老化的常见表现，尤其是在手背上。通常建议使用漂白剂来减轻病变的颜色。
该研究为随机设计，旨在评估含有2%甲萘醌（4-羟基茴香醚，4HA）和0.01%维甲酸（Solagé）的漂白溶液的效果。该制剂每天在一只手背上的日光性雀斑上涂抹两次，持续3个月。另一只手上的病变用乙醇载体进行治疗，作为对照。通过皮肤镜检查确认临床诊断。此外，在治疗期间和治疗后每隔1个月对色素沉着过度进行客观测量。采用临床评估以及窄带反射分光光度法、视频记录的紫外线增强可视化图像分析（ULEV法）和角质层黑素测定试验的光密度测定法。
对病变颜色的多方面评估表明，4HA/维甲酸溶液具有显著的美白效果。这在治疗2个月后得到证实，并在停止治疗后至少维持2个月。
视觉评分和客观生物仪器方法均表明4HA/维甲酸制剂具有快速美白效果。停止治疗后，与色素脱失阶段相比，色素再沉着的速度似乎有所减慢。
