Perçinel Sibel, Savaş Berna, Yilmaz Güldal, Erinanç Hilal, Küpana Ayva Sebnem, Bektaş Mehmet, Ensari Arzu
Department of Pathology, Ankara University, School of Medicine, Ankara, Turkey.
Turk J Gastroenterol. 2008 Sep;19(3):184-8.
The esophagus is the most common site of origin of gastrointestinal tract granular cell tumors. Approximately 270 cases of esophageal granular cell tumors have been reported in the literature. Most esophageal granular cell tumors are found incidentally during endoscopy. Although granular cell tumor of the esophagus has become easily recognizable by its endoscopic features, it has to be differentiated from other benign and malignant mucosal and submucosal lesions. The majority of esophageal granular cell tumors are asymptomatic and benign; thus, close follow-up of the patients with endoscopy could be considered sufficient as a therapeutic management. New therapeutic options should be considered especially for larger lesions. Three cases of granular cell tumors with complaints of epigastric discomfort, regurgitation, nausea, and vomiting, which were detected in the lower part of the esophagus on upper gastrointestinal tract endoscopy, are discussed with the most recent literature review on this subject.
食管是胃肠道颗粒细胞瘤最常见的起源部位。文献中已报道了约270例食管颗粒细胞瘤。大多数食管颗粒细胞瘤是在内镜检查时偶然发现的。尽管食管颗粒细胞瘤通过其内镜特征已变得易于识别，但仍需与其他良性和恶性的黏膜及黏膜下病变相鉴别。大多数食管颗粒细胞瘤无症状且为良性；因此，作为治疗管理手段，可认为对患者进行内镜密切随访就足够了。对于较大的病变，应考虑新的治疗选择。本文结合该主题的最新文献综述，讨论了3例在上消化道内镜检查中于食管下段发现的伴有上腹部不适、反流、恶心和呕吐症状的颗粒细胞瘤病例。
