Electrophysiological connections of the rat mediobasal hypothalamus with brain areas mediating adrenocortical responses.

With the purpose of correlating neuroendocrine and neurophysiological data, the effects of stimulating brain areas which have been shown to be involved in the mediation of adrenocortical reponses, i.e. pontine reticular formation (PRF), mammillary peduncle (MP), medial forebrain bundle (MFB), and the suprachiasmatic nucleus (SCN), were studied on unit activity in the mediobasal hypothalamus in the rat. About half of the units recorded responded significantly to one of these modalities by a change in the rate of firing, the MP producing mainly inhibition and SCN facilitation and changes also occurred in the post-stimulus histograms. There was a convergence of different modalities on the same hypothalamic unit. No changes occurred in the time-interval histograms. Stimulating the mediobasal hypothalamus activated synaptically units in the PRF, MP, and MFB but none of them were activated antidromically. The present data demonstrate electrophysiological connections between extrahypothalamic regions participating in adrenocortical regulation and the hypophysiotropic area of the hypothalamus.