Papir-Kricheli D, Feldman S
Brain Res Bull. 1980 Nov-Dec;5(6):759-63. doi: 10.1016/0361-9230(80)90217-8.
In view of the role of extrahypothalamic influences on the hypothalamic regulatory activity, the effects of anterior, anterolateral or posterolateral hypothalamic deafferentations and bilateral medial forebrain bundle (MFB) lesions on the spontaneous single cell activity of neurons in the mediobasal hypothalamus (MBH) were studied in rats under urethane anesthesia. While the deafferentation and particularly the anterior cuts reduced the average rates, MFB lesions increased the rate of firing of MBH neurons, and revealed cyclic activity. These data indicate that normally anterior afferents have mainly a facilitatory, while the MFB projections to the MBH have an inhibitory effect on the spontaneous activity. The possible relation of these alterations to neuroendocrine changes are discussed.
鉴于下丘脑外影响对下丘脑调节活动的作用，我们在乌拉坦麻醉的大鼠中研究了下丘脑前侧、前外侧或后外侧去传入神经支配以及双侧内侧前脑束（MFB）损伤对下丘脑中间基底部（MBH）神经元自发单细胞活动的影响。去传入神经支配，尤其是前侧切断，降低了平均发放率，而MFB损伤则增加了MBH神经元的发放率，并显示出周期性活动。这些数据表明，正常情况下，前侧传入神经主要起促进作用，而投射到MBH的MFB具有抑制自发活动的作用。本文讨论了这些改变与神经内分泌变化的可能关系。
