Archer K F, Hurwitz J J, Heathcote G
Department of Ophthalmology, University of Texas Health Science Center, San Antonio.
Ophthalmic Plast Reconstr Surg. 1991;7(3):208-21. doi: 10.1097/00002341-199109000-00010.
Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon, benign slow-growing lesion primarily found in the head and neck region, with onset between the third and fourth decades, and a female predominance in the nonOriental population. Kimura's disease, occurring primarily in young Oriental males, is a similar lesion with peripheral blood eosinophilia, regional lymphadenopathy, and occasional nephrotic syndrome. Orbital ALHE is rare, previously reported in only nine patients. Orbital ALHE is a solitary lesion, with an older age of onset, between the fourth and eighth decades, than ALHE elsewhere. There is a male predominance, in contradistinction to ALHE elsewhere in nonOrientals. Orbital ALHE demonstrates the same histology as other locations, with exuberant capillary proliferation and an inflammatory infiltrate of eosinophils, lymphocytes, plasma cells, and mast cells. The maturity of the lesion, not necessarily the duration, determines the presence of lymphoid follicles and germinal centers. A distinctive endothelial cell lines and even extends into the vascular lumens. Peripheral blood eosinophilia occasionally occurs, and a few cases have been reported in conjunction with asthma. Therapeutic regimens for ALHE include excision, carbon dioxide and argon laser, irradiation, steroids, electrodesiccation, and cytotoxic agents. Orbital lesions have been treated successfully with excision, or biopsy with debulking, or steroids.
嗜酸性粒细胞增多性血管淋巴样增生（ALHE）是一种罕见的、生长缓慢的良性病变，主要见于头颈部，发病年龄在第三和第四个十年之间，在非东方人群中女性占主导。木村病主要发生在年轻的东方男性中，是一种类似的病变，伴有外周血嗜酸性粒细胞增多、局部淋巴结病，偶尔伴有肾病综合征。眼眶ALHE很罕见，此前仅报道过9例。眼眶ALHE是一种孤立性病变，发病年龄比其他部位的ALHE大，在第四和第八个十年之间。与非东方人其他部位的ALHE不同，眼眶ALHE以男性为主。眼眶ALHE的组织学表现与其他部位相同，有丰富的毛细血管增生以及嗜酸性粒细胞、淋巴细胞、浆细胞和肥大细胞的炎性浸润。病变的成熟度而非持续时间决定了淋巴滤泡和生发中心的存在。有一种独特的内皮细胞系，甚至延伸到血管腔。外周血偶尔会出现嗜酸性粒细胞增多，有少数病例报告与哮喘有关。ALHE的治疗方案包括切除、二氧化碳和氩激光治疗、放疗、类固醇、电干燥和细胞毒性药物。眼眶病变已通过切除、或减瘤活检、或类固醇治疗成功治愈。
