Ishii N, Ishii H, Nakajima H, Aoki I, Shimoda N
Department of Dermatology, Yokohama City University School of Medicine, Japan.
J Dermatol Sci. 1991 Jul;2(4):268-73. doi: 10.1016/0923-1811(91)90050-8.
Genetic control of contact sensitivity to mercuric chloride antigen was studied using various strains on inbred mice. Mice with class II Ab,d,f,s haplotypes showed a high magnitude of response, whereas those with class II Ak,q were low responders. These results indicate that mercuric chloride contact sensitivity may be influenced by the I-A region of H-2. Transfer experiments revealed that these responses might be mediated by L3T4+, Lyt-2- T cells. However Lyt-2+ T cells do not suppress the DTH response.
利用多种近交系小鼠品系研究了对氯化汞抗原接触敏感性的遗传控制。具有II类Ab、d、f、s单倍型的小鼠表现出高反应程度，而具有II类Ak、q单倍型的小鼠则是低反应者。这些结果表明，氯化汞接触敏感性可能受H-2的I-A区域影响。转移实验显示，这些反应可能由L3T4+、Lyt-2-T细胞介导。然而，Lyt-2+T细胞并不抑制迟发型超敏反应。
