Ishii N, Ishii H, Ono H, Horiuchi Y, Nakajima H, Aoki I
Department of Dermatology, Yokohama City University School of Medicine, Kanagawa, Japan.
J Invest Dermatol. 1990 May;94(5):673-6. doi: 10.1111/1523-1747.ep12876249.
Genetic control of delayed-type hypersensitivity (DTH) to nickel sulfate antigen was studied using various strains on inbred mice. Mice with class II Ad,k,s haplotypes showed a high magnitude of response, whereas those with class II Ab,f were low responders. These results indicate that nickel sulfate DTH may be influenced by the I-A region of H-2. Transfer experiments revealed that these responses might be mediated by L3T4+, Lyt-2- T cells.
利用各种近交系小鼠品系研究了对硫酸镍抗原的迟发型超敏反应（DTH）的遗传控制。具有II类Ad、k、s单倍型的小鼠表现出高反应程度，而具有II类Ab、f单倍型的小鼠是低反应者。这些结果表明，硫酸镍DTH可能受H-2的I-A区域影响。转移实验显示，这些反应可能由L3T4+、Lyt-2-T细胞介导。
