一种强效的新型β2肾上腺素能受体阻断剂。
A potent new beta2-adrenoceptor blocking agent.
作者信息
Imbs J L, Miesch F, Schwartz J, Velly J, Leclerc G, Mann A, Wermuth C G
出版信息
Br J Pharmacol. 1977 Jul;60(3):357-62. doi: 10.1111/j.1476-5381.1977.tb07508.x.
Abstract
1 (t-Butyl-amino-3-ol-2-propyl) oximino-9 fluorene is a new beta2-adrenoceptor blocking agent with a pA2 of 9.23+/-0.25 on isolated trachea. 2 It provokes hypertension in normotensive rats and does not prevent arterial hypertension in SHR rats, although it does prevent the renin secretion normally induced by isoprenaline infusion.
摘要
- （叔丁基氨基 -3- 羟基 -2- 丙基）肟基芴是一种新型β2 - 肾上腺素能受体阻滞剂，在离体气管上的pA2为9.23±0.25。2. 它可使正常血压大鼠产生高血压，并且不能预防SHR大鼠的动脉高血压，尽管它能阻止异丙肾上腺素输注正常诱导的肾素分泌。
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