在体内，Wnt信号传导靶向TAF4/TFIID的ETO共激活结构域。
Wnt signaling targets ETO coactivation domain of TAF4/TFIID in vivo.
作者信息
Wright Kevin J, Tjian Robert
机构信息
Howard Hughes Medical Institute, Li Ka-Shing Center for Biomedical and Sciences, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
出版信息
Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):55-60. doi: 10.1073/pnas.0811914106. Epub 2008 Dec 30.
Abstract
Understanding the diverse activities of the multisubunit core promoter recognition complex TFIID in vivo requires knowledge of how individual subunits contribute to overall functions of this TATA box-binding protein (TBP)/TBP-associated factor (TAF) complex. By generating altered holo-TFIID complexes in Drosophila we identify the ETO domain of TAF4 as a coactivator domain likely targeted by Pygopus, a protein that is required for Wingless-induced transcription of naked cuticle. These results establish a coactivator function of TAF4 and provide a strategy to dissect mechanisms of TFIID function in vivo.
摘要
要了解多亚基核心启动子识别复合物TFIID在体内的多种活性，需要知道各个亚基如何对这种TATA盒结合蛋白（TBP）/TBP相关因子（TAF）复合物的整体功能做出贡献。通过在果蝇中生成改变的全酶TFIID复合物，我们确定TAF4的ETO结构域是一种可能被Pygoopus靶向的共激活结构域，Pygoopus是无翅诱导的裸表皮转录所必需的一种蛋白质。这些结果确立了TAF4的共激活功能，并提供了一种剖析TFIID在体内功能机制的策略。
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2
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3
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