来自内生地衣真菌拟盘多毛孢属（Pestalotiopsis sp.）的ambuic酸和torreyanic酸衍生物

Ambuic acid and torreyanic acid derivatives from the endolichenic fungus Pestalotiopsis sp.

作者信息

Ding Gang, Li Yan, Fu Shaobin, Liu Shuchun, Wei Jiangchun, Che Yongsheng

机构信息

Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.

出版信息

J Nat Prod. 2009 Jan;72(1):182-6. doi: 10.1021/np800733y.

DOI:10.1021/np800733y

PMID:19117486

Abstract

Six new ambuic acid (1) derivatives (2-7) and a new torreyanic acid analogue (8) have been isolated from the crude extract of endophytic fungus Pestalotiopsis sp. inhabiting the lichen Multiclavula [corrected] sp. The structures of these compounds were elucidated primarily by NMR and MS methods, and their absolute configurations were assigned by application of the CD excitation chirality method. Compounds 1 and 2 displayed antimicrobial activity against the Gram-positive bacterium Staphylococcus aureus.

摘要

从栖息于地衣多枝多盘菌（[已修正]）中的内生真菌拟盘多毛孢属菌株的粗提物中分离出了6种新的ambuic酸（1）衍生物（2 - 7）和1种新的torreyanic酸类似物（8）。这些化合物的结构主要通过核磁共振（NMR）和质谱（MS）方法阐明，其绝对构型通过圆二色（CD）激发手性方法确定。化合物1和2对革兰氏阳性菌金黄色葡萄球菌显示出抗菌活性。