Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People's Republic of China.
J Nat Prod. 2011 Feb 25;74(2):286-91. doi: 10.1021/np100723t. Epub 2011 Feb 8.
Two new isoprenylated epoxyquinol derivatives, pestaloquinols A (2) and B (3), and their putative biosynthetic precursor, cytosporin D (1), were isolated from the crude extract of the plant endophytic fungus Pestalotiopsis sp. The structures of these compounds were elucidated primarily by NMR experiments. Pestaloquinols A (2) and B (3) possess a previously undescribed nonacyclic ring system and showed cytotoxicity against HeLa cells.
从植物内生真菌 Pestalotiopsis sp 的粗提物中分离得到了两个新的异戊烯基环氧喹啉衍生物，pestaloquinols A（2）和 B（3），以及它们的假定生物合成前体，cytosporin D（1）。这些化合物的结构主要通过 NMR 实验阐明。 Pestaloquinols A（2）和 B（3）具有以前未描述的非环体系，对 HeLa 细胞表现出细胞毒性。
