Heyerdahl Fridtjof, Bjornaas Mari Asphjell, Dahl Rune, Hovda Knut Erik, Nore Anne Kathrine, Ekeberg Oivind, Jacobsen Dag
Department of Acute Medicine, Ullevaal University Hospital, Oslo, Norway.
Br J Psychiatry. 2009 Jan;194(1):73-9. doi: 10.1192/bjp.bp.107.048322.
The repetition of acute poisoning occurs frequently. The intention may change between episodes and many poisonings are treated outside the hospital setting. Few studies have taken this into account.
To quantify the repetition frequency regardless of the level of health care or the intention behind the poisoning, and to identify possible risk factors for repetition.
A prospective multicentre study of all acute poisonings in Oslo treated in hospital, at an out-patient clinic or by the ambulance service. Repetition was estimated using Kaplan-Meier calculations, and predictive factors were identified using Cox regression analysis.
The estimated 1-year repetition rate was 30% (95% CI 24-35). Independent predictors of repetition were middle age (30-49 years), poisoning with opiates or sedatives, unemployment or living on social welfare, a previous suicide attempt, and a history of psychiatric treatment. Intention was not a significant predictor.
Repetition of acute poisoning is high, irrespective of the level of healthcare and the intention behind the poisoning.
急性中毒的反复发生屡见不鲜。各次中毒事件的意图可能有所变化，而且许多中毒事件是在院外进行治疗的。很少有研究考虑到这一点。
不计医疗保健水平或中毒背后的意图，量化反复发生的频率，并确定反复发生的可能风险因素。
对奥斯陆所有在医院、门诊诊所或由救护车服务处理的急性中毒事件进行一项前瞻性多中心研究。使用Kaplan-Meier计算法估计反复发生情况，并使用Cox回归分析确定预测因素。
估计的1年反复发生率为30%（95%可信区间24 - 35）。反复发生的独立预测因素为中年（30 - 49岁）、阿片类药物或镇静剂中毒、失业或依靠社会福利生活、既往自杀未遂以及有精神科治疗史。意图并非显著的预测因素。
急性中毒的反复发生率很高，无论医疗保健水平及中毒背后的意图如何。
