van Goor Saskia A, Dijck-Brouwer D A Janneke, Hadders-Algra Mijna, Doornbos Bennard, Erwich Jan Jaap H M, Schaafsma Anne, Muskiet Frits A J
Pathology and Laboratory Medicine, UMCG, University Medical Center Groningen, The Netherlands.
Prostaglandins Leukot Essent Fatty Acids. 2009 Jan;80(1):65-9. doi: 10.1016/j.plefa.2008.11.002. Epub 2008 Dec 31.
Docosahexaenoic acid (DHA) and arachidonic acid (AA) are important for neurodevelopment. Maternal diet influences milk DHA, whereas milk AA seems rather constant. We investigated milk AA, DHA and DHA/AA after supplementation of AA plus DHA, or DHA alone during pregnancy and lactation.
Women were supplemented with AA+DHA (220mg each/day), DHA (220mg/day) or placebo during pregnancy and lactation. Milk samples were collected at 2 (n=86) and 12 weeks (n=69) postpartum.
Supplementation of AA+DHA elevated milk AA (week 2, 14%; week 12, 23%) and DHA (43% and 52%) as compared to placebo. DHA tended to decrease milk AA and vice versa. Milk AA, DHA and DHA/AA decreased from 2 to 12 weeks postpartum.
Milk AA and in particular DHA are sensitive to maternal supplementation. It seems that maternal AA and notably DHA status decline with advancing lactation.
二十二碳六烯酸（DHA）和花生四烯酸（AA）对神经发育很重要。母亲的饮食会影响乳汁中的DHA含量，而乳汁中的AA含量似乎相当稳定。我们研究了在孕期和哺乳期补充AA加DHA或仅补充DHA后乳汁中AA、DHA和DHA/AA的情况。
女性在孕期和哺乳期补充AA+DHA（各220毫克/天）、DHA（220毫克/天）或安慰剂。产后2周（n = 86）和12周（n = 69）采集乳汁样本。
与安慰剂相比，补充AA+DHA可使乳汁中的AA（第2周，14%；第12周，23%）和DHA（分别为43%和52%）升高。DHA有降低乳汁中AA的趋势，反之亦然。产后2至12周，乳汁中的AA、DHA和DHA/AA均下降。
乳汁中的AA尤其是DHA对母亲补充剂敏感。随着哺乳期延长，母亲的AA尤其是DHA水平似乎会下降。
