da Costa Leodante, Dehdashti Amir R, terBrugge Karel G
Division of Neurosurgery, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Canada.
Neurosurg Focus. 2009 Jan;26(1):E6. doi: 10.3171/FOC.2009.26.1.E6.
Spinal cord vascular malformations are rare, fascinating lesions. In this paper, the authors' goal was to demonstrate how these lesions, more specifically spinal cord arteriovenous malformations and dural arteriovenous fistulas, are assessed, classified, and managed at their institution. They also highlight some aspects of classification and management that may be different from the views of others.
The authors reviewed the 20-year experience at the senior author's institution regarding the management of spinal cord vascular malformations. They discuss the management, surgical and endovascular treatment results, and the classification that resulted from the combined experience of 3 major reference centers.
The accumulated knowledge on embryological and pathophysiological aspects in such a rare disease resulted in a more global, patient-oriented (and not radiologically oriented) approach to spinal cord shunts.
The multiple classifications proposed for spinal cord vascular malformations reflect the continuous advancement of the authors' understanding. They adopt a classification based on new physiological and genetic data that treats these lesions as expressions of more complex disease processes and not simply a morphological target, with direct impact on therapeutic options.
脊髓血管畸形是罕见且引人关注的病变。在本文中,作者的目标是展示在他们的机构中如何评估、分类和处理这些病变,更具体地说是脊髓动静脉畸形和硬脊膜动静脉瘘。他们还强调了一些分类和处理方面可能与其他人观点不同之处。
作者回顾了资深作者所在机构20年来关于脊髓血管畸形处理的经验。他们讨论了处理方法、手术和血管内治疗结果,以及由3个主要参考中心的综合经验得出的分类。
在这种罕见疾病中积累的关于胚胎学和病理生理学方面的知识,促成了一种更全面、以患者为导向(而非以放射学为导向)的脊髓分流处理方法。
针对脊髓血管畸形提出的多种分类反映了作者认识的不断进步。他们采用基于新的生理学和遗传学数据的分类方法,将这些病变视为更复杂疾病过程的表现,而不仅仅是形态学靶点,这对治疗选择有直接影响。