Rodríguez Camarillo Sergio D, García Ortiz Miguel Angel, Rojas Ramírez Edmundo E, Cantó Alarcón Germinal J, Preciado de la Torre Jesús F, Rosario Cruz Rodrigo, Ramos Aragón Juan A, Aboytes Torres Ramón
Centro de Investigaciones Disciplinarias, en Parasitología Veterinaria, Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, Secretaría de Agricultura, Ganadería, Desarrollo Rural, Pesca y Alimentació, Jiutepec, Morelos, Méxcio.
Ann N Y Acad Sci. 2008 Dec;1149:98-102. doi: 10.1196/annals.1428.067.
Anaplasma marginale Yucatan strain was found to have low virulence in cattle. We studied the virulence of this isolate by experimental inoculation of 113 susceptible cattle at increasing doses, after which only one animal required treatment for clinical disease. Subsequently, 104 cattle received a live vaccine of this strain by inoculation, which induced immunoprotection after heterologous challenged exposure with a different A. marginale isolate. In this study 14% of the immunized cattle required treatment as compared with the control nonimmunized cattle, in which 56% required treatment. The A. marginale vaccine strains used for the immunization studies had MSP1a variable regions that were different from those used for the challenge exposure.
边缘无形体尤卡坦菌株在牛群中表现出低毒力。我们通过以递增剂量对113头易感牛进行实验性接种来研究该分离株的毒力，之后只有1头牛因临床疾病需要治疗。随后，104头牛接种了该菌株的活疫苗，在接受不同的边缘无形体分离株进行异源攻击暴露后诱导了免疫保护。在本研究中，与未免疫的对照牛相比，14%的免疫牛需要治疗，而对照牛中有56%需要治疗。用于免疫研究的边缘无形体疫苗株的MSP1a可变区与用于攻击暴露的不同。
