Abdala A A, Pipano E, Aguirre D H, Gaido A B, Zurbriggen M A, Mangold A J, Guglielmone A A
INTA C.C 22, Santa Fe, Argentina.
Rev Elev Med Vet Pays Trop. 1990;43(2):155-8.
The immunity induced by frozen and fresh Anaplasma centrale vaccines against anaplasmosis caused by A. marginale was tested in 12-month old Friesian steers. A. centrale parasitaemia occurred in all cattle inoculated with both types of vaccine. The average maximal decrease in PCV for the frozen and fresh vaccines was 41.0 and 40.3% respectively. All cattle recovered spontaneously. Vaccinated and control steers of the same age were challenged six months later with doses of 10(6), 10(7) or 10(8) A. marginale organisms. Vaccinated cattle showed average maximal A. marginale parasitemia of 1.2-4.0 versus 10.3-12.0% in control cattle. The average maximal decrease in packed cell volume (PCV) was 33.1 and 30.0% for steers vaccinated with frozen or fresh vaccine, respectively, and 57.4% for the non-vaccinated steers. All vaccinated cattle recovered spontaneously from the A. marginale infection while 7 out of 8 control steers required specific treatment. It thus appears that both frozen and fresh A. centrale vaccines are equally capable of inducing partial protection against infection with A. marginale and of preventing severe red blood cell destruction.
在12月龄的弗里斯兰公牛中测试了冷冻和新鲜的中央无形体疫苗诱导的针对边缘无形体引起的无形体病的免疫力。接种两种疫苗的所有牛均出现中央无形体血症。冷冻疫苗和新鲜疫苗导致的血细胞比容（PCV）平均最大降幅分别为41.0%和40.3%。所有牛均自发康复。6个月后，用10⁶、10⁷或10⁸个边缘无形体生物体对相同年龄的接种疫苗的公牛和对照公牛进行攻毒。接种疫苗的牛的边缘无形体平均最大寄生虫血症为1.2% - 4.0%，而对照牛为10.3% - 12.0%。接种冷冻或新鲜疫苗的公牛的红细胞压积（PCV）平均最大降幅分别为33.1%和30.0%，未接种疫苗的公牛为57.4%。所有接种疫苗的牛均从边缘无形体感染中自发康复，而8头对照公牛中有7头需要进行特殊治疗。因此，冷冻和新鲜的中央无形体疫苗似乎同样有能力诱导对边缘无形体感染的部分保护，并防止严重的红细胞破坏。
