Squier C A
Dows Institute for Dental Research, University of Iowa, College of Dentistry, Iowa City 52242.
Crit Rev Oral Biol Med. 1991;2(1):13-32. doi: 10.1177/10454411910020010301.
In discussing permeability, we are describing one of the fundamental barrier functions of oral mucosa. Despite assumptions to the contrary, the oral mucosa is not a uniformly, highly permeable tissue like gut, but shows regional variation. The keratinized areas, such as gingiva and hard palate, are least permeable and nonkeratinized lining areas are most permeable. This variation appears to reflect differences in the types of lipid making up the intercellular permeability barrier in the superficial layers of the epithelium. Differences in permeability may be related to regional differences in the prevalence of certain mucosal diseases and can be utilized to advantage for local and systemic drug delivery.
在讨论渗透性时，我们描述的是口腔黏膜的基本屏障功能之一。尽管有相反的假设，但口腔黏膜并非像肠道那样是一种均匀、高渗透性的组织，而是存在区域差异。角化区域，如牙龈和硬腭，渗透性最低，而非角化的衬里区域渗透性最高。这种差异似乎反映了构成上皮表层细胞间渗透屏障的脂质类型的不同。渗透性的差异可能与某些黏膜疾病患病率的区域差异有关，并且可被用于局部和全身给药的优势。
