Castelli W P, Doyle J T, Gordon T, Hames C G, Hjortland M C, Hulley S B, Kagan A, Zukel W J
Circulation. 1977 May;55(5):767-72. doi: 10.1161/01.cir.55.5.767.
The relation between coronary heart disease (CHD) prevalence and fasting lipid levels was assessed by a case-control study in five populations with a total of 6859 men and women of black, Japanese and white ancestry drawn from subjects aged 40 years and older from populations in Albany, Framingham, Evans County, Honolulu and San Francisco. In each major study group mean levels of high density lipoprotein (HDL) cholesterol were lower in persons with CHD than in those without the disease. The average difference was small -- typically 3-4 mg/dl -- but statistically significant. It was found in most age-race-sex specific groups. The inverse HDL cholesterol-CHD association was not appreciably diminished when adjusted for levels of low density lipoprotein (LDL) cholesterol and triglyceride. LDL, totoal cholesterol and triglycerides were directly related to CHD prevalence; surprisingly, these findings were less uniformly present in the various study groups than the inverse HDL cholesterol-CHD association.
通过一项病例对照研究，对来自奥尔巴尼、弗雷明汉、埃文斯县、檀香山和旧金山的40岁及以上人群中总计6859名黑人、日本人和白人血统的男性和女性组成的五个人群的冠心病（CHD）患病率与空腹血脂水平之间的关系进行了评估。在每个主要研究组中，冠心病患者的高密度脂蛋白（HDL）胆固醇平均水平低于无该病者。平均差异较小——通常为3 - 4mg/dl——但具有统计学意义。在大多数年龄 - 种族 - 性别特定组中均发现了这一现象。在对低密度脂蛋白（LDL）胆固醇和甘油三酯水平进行调整后，HDL胆固醇与冠心病的负相关关系并未明显减弱。LDL、总胆固醇和甘油三酯与冠心病患病率直接相关；令人惊讶的是，与HDL胆固醇与冠心病的负相关关系相比，这些发现在各个研究组中的一致性较差。
