Cândido Flávia Galvão, da Silva Alessandra, Zanirate Gilmara Alves, Oliveira Nathallia Maria Cotta E, Hermsdorff Helen Hermana Miranda
Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa-MG, 36570-900, Brazil.
Laboratory of Health and Environment Education, Instituto Oswaldo Cruz, Av. Brasil, 4365, Manguinhos, 21040-360 Rio de Janeiro, Rio de Janeiro, Brazil.
Inflammation. 2025 Feb;48(1):276-287. doi: 10.1007/s10753-024-02063-w. Epub 2024 Jun 6.
High scores of lymphocyte-to-high-density lipoprotein cholesterol ratio (lymphocyte-to-HDL-c) may be a new indicator of inflammation and metabolic syndrome. Here, we investigated the associations of the lymphocyte-to-HDL-c with traditional and non-traditional cardiometabolic risk markers in subjects at high cardiovascular risk. This study is a cross-sectional analysis with subjects assisted in a Secondary Health Care (n = 581, age = 63.06 ± 13.86 years; 52.3% women). Lymphocyte-to-HDL-c ratio were assessed by routine laboratory tests. Anthropometric and/or biochemical variables were used to calculate traditional (body mass index - BMI, and waist-to-height ratio - WHtR) and non-traditional (lipid accumulation product index-LAP, visceral adiposity index-VAI, deep-abdominal-adipose-tissue index-DAAT, atherogenic index of plasma-AIP, and waist-hypertriglyceridemic phenotype-HTGW) cardiometabolic risk markers. Furthermore, anthropometric measurement waist circumference (WC), blood pressure, metabolic syndrome (MS), and biochemical markers (lipid and glycemic profile) were considered traditional markers of cardiometabolic risk. Pearson's chi-square test, Poisson regression with robust variance, or multinomial logistic regression were performed (α = 0.05). Individuals with a high lymphocyte-HDL-c ratio (> 0.84, 3rd tertile) were associated with the HTGW phenotype, high VAI, high LAP, hypertriglyceridemia, high AIP, high very low-density lipoprotein-cholesterol (VLDL-c), pre-diabetes, and 3 and 4 MS components compared with individuals in the first tertile, independent of confounders. Our findings supported the lymphocyte-to-HDL-c ratio as a potential biomarker during the screening of subjects at high cardiovascular risk.
淋巴细胞与高密度脂蛋白胆固醇比值（淋巴细胞与高密度脂蛋白胆固醇比值）较高可能是炎症和代谢综合征的新指标。在此，我们研究了淋巴细胞与高密度脂蛋白胆固醇比值与心血管疾病高风险受试者的传统和非传统心脏代谢风险标志物之间的关联。本研究是一项横断面分析，研究对象为接受二级医疗保健的受试者（n = 581，年龄 = 63.06 ± 13.86岁；52.3%为女性）。通过常规实验室检测评估淋巴细胞与高密度脂蛋白胆固醇比值。使用人体测量和/或生化变量来计算传统（体重指数 - BMI，以及腰高比 - WHtR）和非传统（脂质蓄积产物指数 - LAP、内脏脂肪指数 - VAI、腹部深层脂肪组织指数 - DAAT、血浆致动脉粥样硬化指数 - AIP，以及腰围高甘油三酯血症表型 - HTGW）心脏代谢风险标志物。此外，人体测量腰围（WC）、血压、代谢综合征（MS）和生化标志物（血脂和血糖谱）被视为心脏代谢风险的传统标志物。进行了Pearson卡方检验、具有稳健方差的泊松回归或多项逻辑回归（α = 0.05）。与第一三分位数的个体相比，淋巴细胞 - 高密度脂蛋白胆固醇比值较高（> 0.84，第三三分位数）的个体与HTGW表型、高VAI、高LAP、高甘油三酯血症、高AIP、高极低密度脂蛋白胆固醇（VLDL - c）、糖尿病前期以及3个和4个MS组分相关，且独立于混杂因素。我们的研究结果支持淋巴细胞与高密度脂蛋白胆固醇比值作为心血管疾病高风险受试者筛查期间的潜在生物标志物。
