Tsvetkova V
Curr Med Res Opin. 1977;4(7):477-84. doi: 10.1185/03007997709109336.
Daily fluctuations in plasma cortisol levels were studied in three groups of children with rheumatoid arthritis. One group was untreated with hormones, the second treated with a depot preparation of tetracosactrin, and the third group with corticosteroid hormones. The results obtained were compared with the rhythm in normal children. The daily plasma cortisol fluctuations in children with rheumatoid arthritis who did not receive hormonal treatment differed from those of normal children by the presence of two distinct and characteristic cortisol levels: a peak between 8 a.m. and 12 noon and a minimal level between 4 p.m. and midnight (with a gradual rise after 4 p.m.). The curve of the daily cortisol rhythm in children with rheumatoid arthritis after tetracosactrin treatment was characteristic of the curve in normal children. Steroidtreated children with rheumatoid arthritis had virtually unchanged plasma cortisol concentrations throughout the day.
对三组类风湿性关节炎患儿的血浆皮质醇水平的每日波动情况进行了研究。一组未接受激素治疗，第二组接受长效四肽促肾上腺皮质激素制剂治疗，第三组接受皮质类固醇激素治疗。将所得结果与正常儿童的节律进行了比较。未接受激素治疗的类风湿性关节炎患儿的血浆皮质醇每日波动情况与正常儿童不同，表现为存在两个明显且具有特征性的皮质醇水平：上午8点至中午12点之间出现峰值，下午4点至午夜之间出现最低水平（下午4点后逐渐上升）。接受四肽促肾上腺皮质激素治疗的类风湿性关节炎患儿的每日皮质醇节律曲线具有正常儿童曲线的特征。接受类固醇治疗的类风湿性关节炎患儿全天血浆皮质醇浓度几乎没有变化。
