Hugh-Jones P, Pearson R S, Booth M
Thorax. 1975 Aug;30(4):426-9. doi: 10.1136/thx.30.4.426.
Thirty-five of 41 asthmatic patients, who had been taking oral corticosteroids regularly for between one and 12 years, recovered their adrenal function after courses of depot tetracosactrin, even those with apparently complete adrenal suppression. They all showed benefit by transfer to depot tetracosactrin, though steroid withdrawal symptoms could be troublesome. Skin pigmentation in three, and two severe reactions to tetracosactrin were encountered. We believe that it is advisable to give depot tetracosactrin when converting severe asthmatics to the use of beclomethasone dipropionate aerosols who have previously been treated by long-term steroids with consequent adrenal suppression.
41名长期口服皮质类固醇1至12年的哮喘患者中，有35名在接受长效四氢促皮质素治疗后恢复了肾上腺功能，即便那些肾上腺功能明显完全受抑制的患者也是如此。尽管停用类固醇药物时的症状可能令人不适，但他们改用长效四氢促皮质素治疗后均有好转。有3例出现皮肤色素沉着，2例对四氢促皮质素出现严重反应。我们认为，对于之前长期使用类固醇药物导致肾上腺抑制的重度哮喘患者，在转换为使用丙酸倍氯米松气雾剂时，给予长效四氢促皮质素是可取的。
