Nakayama F, Koga A, Ichimiya H, Todo S, Shen K, Guo R X, Zeng X J, Zhang Z H
Department of Surgery I, Kyushu University Faculty of Medicine, Fukuoka, Japan.
J Gastroenterol Hepatol. 1991 Mar-Apr;6(2):155-8. doi: 10.1111/j.1440-1746.1991.tb01457.x.
The incidence of hepatolithiasis is high throughout East Asia compared with the West, but the marked difference in the relative proportion of hepatolithiasis to all cholelithiasis cases exists even among countries of similar ethnic backgrounds. A retrospective study of cases was conducted in two areas in China with the aim of clarifying the presence of such regional difference in China itself. The relative proportion of hepatolithiasis was 21.2% in Shenyang, 9.2% in Beijing and 4.1% in Fukuoka, Japan. A significant difference in the location of stones was also found between Shenyang, Beijing and Fukuoka. Intra- and extrahepatic hepatolithiasis in all hepatolithiasis cases was 95% in Shenyang and 75% in Beijing. Involvement of both hepatic lobes was found in 73% in Shenyang and less than 60% in the other two, suggesting that hepatolithiasis of the old form or of an advanced stage still lingers in Shenyang. In conclusion, regional differences in the proportion and the type of hepatolithiasis exist in China itself, as well as in the Chinese population in Taiwan, Hong Kong and Singapore, as previously reported. The possible contribution of environmental factors to the occurrence of hepatolithiasis is again emphasized.
与西方相比，整个东亚地区肝内胆管结石的发病率较高，但即使在种族背景相似的国家之间，肝内胆管结石在所有胆石症病例中所占的相对比例也存在显著差异。在中国的两个地区进行了一项病例回顾性研究，目的是明确中国国内是否存在这种地区差异。肝内胆管结石的相对比例在沈阳为21.2%，在北京为9.2%，在日本福冈为4.1%。沈阳、北京和福冈之间在结石位置上也发现了显著差异。在所有肝内胆管结石病例中，肝内和肝外胆管结石在沈阳占95%，在北京占75%。在沈阳，两肝叶均受累的情况占73%，在其他两个地区则不到60%，这表明陈旧性或晚期肝内胆管结石在沈阳仍然存在。总之，正如之前报道的那样，在中国本土以及中国台湾、香港和新加坡的华人人群中，肝内胆管结石的比例和类型都存在地区差异。再次强调了环境因素对肝内胆管结石发生的可能影响。
