Koga A
Nihon Geka Gakkai Zasshi. 1984 Sep;85(9):1087-92.
Research Group for Hepatolithiasis, Ministry of Health and Welfare, Japanese Government surveyed cases of hepatolithiasis in the member hospitals. Total of 414 cases were collected between 1977 to 1981. They were divided according to the classification of hepatolithiasis proposed by Research Group for the Study of Damage to the Intrahepatic Bile Duct. Four hundred fifteen patients consisting of 186 males and 228 females. Female predominance was statistically significant (p less than 0.05). Age incidence rose rapidly at their thirties and reached the peak at their fifties. Most stones were calcium bilirubinate stones. In IE classification (intrahepatic and extrahepatic classification), they were equally distributed in each subtype. Left lobe predominated (L and LR Type) in hepatic lobe classification. Bile duct stenosis and dilatation were present in 57% and in 95% of the cases respectively. Bile duct stenosis occurred frequently in the left intrahepatic bile ducts. Possible etiological significance of IE classification difference from those confined to hepatic lobe (I type) to those predominantly in extrahepatic bile duct (IE type) were discussed.
日本厚生省肝内胆管结石研究小组对成员医院的肝内胆管结石病例进行了调查。1977年至1981年间共收集到414例病例。这些病例根据肝内胆管损伤研究小组提出的肝内胆管结石分类法进行了划分。415名患者中，男性186名，女性228名。女性占优势具有统计学意义（p小于0.05）。年龄发病率在三十多岁时迅速上升，在五十多岁时达到峰值。大多数结石为胆红素钙结石。在肝内和肝外分类（IE分类）中，各亚型分布均匀。在肝叶分类中，左叶占主导（L型和LR型）。57%的病例存在胆管狭窄，95%的病例存在胆管扩张。胆管狭窄多见于左肝内胆管。讨论了从局限于肝叶（I型）到主要位于肝外胆管（IE型）的IE分类差异可能的病因学意义。
