Getoff Nikola, Schittl Heike, Hartmann Johannes, Quint Ruth Maria
The University of Vienna, Department of Nutritional Sciences, Section Radiation Biology, A-1090 Vienna, Althanstr. 14, UZAII, Austria.
J Photochem Photobiol B. 2009 Mar 3;94(3):179-82. doi: 10.1016/j.jphotobiol.2008.11.009. Epub 2008 Dec 3.
Testosterone (TES; 4-androstene-17beta-ol-3-on) is found for the first time to eject electrons from its singlet excited state in water-ethanol solvent mixture. This ability was very recently also observed for 17beta-estradiol (17betaE2) and progesterone (PRG)/1/. With increasing TES-concentration, the yield of solvated electrons (e(s)(-)) is decreasing, because of "associate" formation. At higher absorbed UV-doses (lambda=254 nm) the e(s)(-) yield is passing a sharp maximum by formation of TES-ethanol adducts, which are able likewise to emit electrons when excited. At prolonged irradiation the resulting photolytic products of TES-ethanol adducts are also able to emit electrons. The capability of the hormones: 17betaE2, PRG and TES to eject electrons and the resulting metabolites, some of which can induce cancer, is discussed.
首次发现睾酮（TES；4-雄烯-17β-醇-3-酮）在水-乙醇溶剂混合物中从其单重激发态发射电子。最近也观察到17β-雌二醇（17βE2）和孕酮（PRG）具有这种能力/1/。随着TES浓度的增加，溶剂化电子（e(s)(-)）的产率降低，这是由于“缔合物”的形成。在较高的紫外吸收剂量（λ=254 nm）下，e(s)(-)产率通过形成TES-乙醇加合物而达到一个尖锐的最大值，这些加合物在激发时同样能够发射电子。在长时间照射下，TES-乙醇加合物产生的光解产物也能够发射电子。讨论了激素17βE2、PRG和TES发射电子的能力以及由此产生的代谢产物，其中一些代谢产物可诱发癌症。
