Department of Gynecologic Endocrinology and Reproductive Medicine, University Hospital of Vienna, Vienna, Austria.
Gynecol Endocrinol. 2011 Jul;27(7):496-503. doi: 10.3109/09513590.2010.495435. Epub 2010 Jun 29.
Recent studies showed that hormones like progesterone, testosterone, etc. can eject [Formula: see text] (solvated electrons). By means of electron transfer processes via the brain, the hormones communicate with other biological systems in the organism. The present study proves that also estrone is able to emit electrons. Their yield strongly depends on the concentration of the hormone, temperature and on the absorbed energy. The metabolites resulting from this process are likewise able to generate electrons, however with much smaller yields. The formation of the estrone metabolites is studied by HPLC-analyses. In vitro experiments with MCF-7 cells demonstrate the distinct effect of progesterone on the carcinogenity of estrone metabolites. Probable reaction mechanisms for explanation of the observed effects are postulated.
最近的研究表明，孕激素、睾酮等激素可以释放 [公式：见正文]（溶剂化电子）。通过大脑中的电子转移过程，这些激素与生物体中的其他生物系统进行通讯。本研究证明雌酮也能够发射电子。它们的产率强烈依赖于激素的浓度、温度和吸收的能量。这个过程产生的代谢物同样能够产生电子，但是产率要小得多。通过 HPLC 分析研究了雌酮代谢物的形成。MCF-7 细胞的体外实验证明了孕激素对雌酮代谢物致癌性的显著影响。提出了可能的反应机制来解释观察到的效应。
