Nakada T, Hida K, Kwee I L
Neurochemistry Research Laboratory, Department of Veterans Affairs Medical Center, Martinez, CA 94553.
Neuroreport. 1991 Jun;2(6):325-8. doi: 10.1097/00001756-199106000-00006.
Taurine, a sulfur amino acid abundant in brain of the fetus and early day neonate, has been postulated to play a major role in mediating the immature brain's unusually high buffering ability for lactic acidosis reported previously. In this study, we directly investigated this 'taurine effect' using a 10-day-old rat pup model and multinuclear (31P and 1H) nuclear magnetic resonance (NMR) in-vivo spectroscopy. Brain of taurine-supplemented pups exhibited significantly higher acid buffering ability against lactic acidosis than age-matched control pups. The study supports the hypothesis that high levels of free cytosolic taurine increase the brain's ability to buffer against lactic acidosis.
牛磺酸是一种在胎儿和早期新生儿大脑中大量存在的含硫氨基酸，据推测它在介导先前报道的未成熟大脑对乳酸酸中毒异常高的缓冲能力方面发挥着重要作用。在本研究中，我们使用10日龄大鼠幼崽模型和多核磁共振（31P和1H）体内光谱技术直接研究了这种“牛磺酸效应”。补充牛磺酸的幼崽大脑对乳酸酸中毒的酸缓冲能力明显高于年龄匹配的对照幼崽。该研究支持了以下假设：高水平的游离胞质牛磺酸可增强大脑对乳酸酸中毒的缓冲能力。
