黄洋葱（葱属植物洋葱）皮中槲皮素氧化产物的抗菌和抗氧化活性。
Antibacterial and antioxidant activities of quercetin oxidation products from yellow onion (Allium cepa) skin.
作者信息
Ramos Freddy A, Takaishi Yoshihisa, Shirotori Miki, Kawaguchi Yousuke, Tsuchiya Koichiro, Shibata Hirofumi, Higuti Tomihiko, Tadokoro Tetsuo, Takeuchi Minoru
机构信息
Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi-l-78-1, Tokushima 770-8505, Japan.
出版信息
J Agric Food Chem. 2006 May 17;54(10):3551-7. doi: 10.1021/jf060251c.
Four new quercetin-derived oxidation products (1-4) and lunularin-4-O-beta-D-glucoside (5) were isolated from a water extract of onion (Allium cepa) skin, together with 17 other known compounds. Antibacterial assays for the isolated compounds showed that 2-(3,4-dihydroxyphenyl)-4,6-dihydroxy-2-methoxybenzofuran-3-one (1) presented selective activity against Helicobacter pylori strains and 3-(quercetin-8-yl)-2,3-epoxyflavanone (4) showed antibacterial activity against MRSA and H. pylori strains at the same time that it increased susceptibility of MRSA to beta-lactams. Evaluation of antioxidant activity against DPPH for the isolated compounds showed that the new derivative compounds (1-4) and 2,5,7,3',4'-pentahydroxy-3,4-flavandione (6) are more active than quercetin.
从洋葱（葱属植物）皮的水提取物中分离出四种新的槲皮素衍生氧化产物（1-4）和半月苔黄素-4-O-β-D-葡萄糖苷（5），以及其他17种已知化合物。对分离出的化合物进行抗菌试验表明，2-(3,4-二羟基苯基)-4,6-二羟基-2-甲氧基苯并呋喃-3-酮（1）对幽门螺杆菌菌株具有选择性活性，3-(槲皮素-8-基)-2,3-环氧黄烷酮（4）对耐甲氧西林金黄色葡萄球菌（MRSA）和幽门螺杆菌菌株均显示抗菌活性，同时它还增加了MRSA对β-内酰胺类药物的敏感性。对分离出的化合物进行的DPPH抗氧化活性评估表明，新的衍生物化合物（1-4）和2,5,7,3',4'-五羟基-3,4-黄烷二酮（6）比槲皮素更具活性。
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