Mirakian R, Ewan P W, Durham S R, Youlten L J F, Dugué P, Friedmann P S, English J S, Huber P A J, Nasser S M
Cambridge University, NHS Foundation Trust, Allergy Clinic, Cambridge, UK.
Clin Exp Allergy. 2009 Jan;39(1):43-61. doi: 10.1111/j.1365-2222.2008.03155.x.
These guidelines have been prepared by the Standards of Care Committee (SOCC) of the British Society for Allergy and Clinical Immunology (BSACI) and are intended for allergists and others with a special interest in allergy. As routine or validated tests are not available for the majority of drugs, considerable experience is required for the investigation of allergic drug reactions and to undertake specific drug challenge. A missed or incorrect diagnosis of drug allergy can have serious consequences. Therefore, investigation and management of drug allergy is best carried out in specialist centres with large patient numbers and adequate competence and resources to manage complex cases. The recommendations are evidence-based but where evidence was lacking consensus was reached by the panel of specialists on the committee. The document encompasses epidemiology, risk factors, clinical patterns of drug allergy, diagnosis and treatment procedures. In order to achieve a correct diagnosis we have placed particular emphasis on obtaining an accurate clinical history and on the physical examination, as these are critical to the choice of skin tests and subsequent drug provocation. After the diagnosis of drug allergy has been established, communication of results and patient education are vital components of overall patient management.
这些指南由英国过敏与临床免疫学会（BSACI）的护理标准委员会（SOCC）制定，面向过敏症专科医生及其他对过敏症有特殊兴趣的人员。由于大多数药物没有常规或经过验证的检测方法，调查药物过敏反应并进行特定药物激发试验需要相当丰富的经验。药物过敏的漏诊或误诊可能会产生严重后果。因此，药物过敏的调查和管理最好在有大量患者、具备足够能力和资源来处理复杂病例的专科中心进行。这些建议基于证据，但在缺乏证据的情况下，委员会的专家小组达成了共识。该文件涵盖了药物过敏的流行病学、风险因素、临床模式、诊断和治疗程序。为了做出正确诊断，我们特别强调获取准确的临床病史和进行体格检查，因为这些对于皮肤试验的选择和后续药物激发试验至关重要。在确诊药物过敏后，结果的传达和患者教育是整体患者管理的重要组成部分。
