Charbonneau Nicolas, Gélinas Michel, del Vecchio Pierre, Guertin Louis, Larochelle Daniel, Tabet Jean-Claude, Souliàres Denis, Charpentier Danielle, Félix Nguyen-Tân Phuc
Department of Hematology-Oncology, Notre-Dame Hospital, Montreal, Quebec.
J Otolaryngol Head Neck Surg. 2008 Aug;37(4):572-6.
To review the Notre-Dame Hospital experience in the treatment of carcinoma in situ of the glottis by radiotherapy and to evaluate the different factors affecting local control and survival.
Between January 1990 and June 2002, 61 patients presenting with carcinoma in situ of the glottis were treated with curative intent radiotherapy. No patients received either surgery or chemotherapy in the initial treatment of their cancer.
The median follow-up for the entire population was 3.2 years. The local control rate was 96% and 94% at 2 and 5 years, respectively. Overall survival was 100% and 90% at 2 and 5 years, respectively. No statistically significant prognostic factor could be identified either for local control or survival. No patient experienced severe treatment complications or death.
Radiotherapy offers excellent treatment results for carcinoma in situ of the glottic larynx, with few treatment complications. These results are comparable to those published in the literature and justify our choice of primary radiotherapy for carcinoma in situ of the glottis.
回顾圣母医院采用放射治疗声门原位癌的经验，并评估影响局部控制和生存的不同因素。
1990年1月至2002年6月期间，61例声门原位癌患者接受了根治性放射治疗。在癌症的初始治疗中，没有患者接受手术或化疗。
全体患者的中位随访时间为3.2年。2年和5年时的局部控制率分别为96%和94%。2年和5年时的总生存率分别为100%和90%。在局部控制或生存方面，未发现具有统计学意义的预后因素。没有患者出现严重的治疗并发症或死亡。
放射治疗为声门原位癌提供了出色的治疗效果，且治疗并发症较少。这些结果与文献中发表的结果相当，证明了我们选择声门原位癌进行原发性放射治疗的合理性。
