放疗在早期声门型喉癌中的作用。

Role of radiotherapy in early glottic carcinoma.

机构信息

Department of Radiation Oncology, The Prince of Wales Cancer Centre, High Street, Randwick, New South Wales 2031, Australia.

出版信息

Head Neck. 2010 Jul;32(7):850-9. doi: 10.1002/hed.21262.

DOI:10.1002/hed.21262

PMID:20029987

Abstract

BACKGROUND

Early glottic carcinoma has a high local control prospect with radiotherapy. This review evaluates a single center's experience.

METHODS

All patients from 1967 to 2006 diagnosed with Tis/T1/T2/N0 early glottic carcinoma treated definitively with radiotherapy at Prince of Wales Hospital were reviewed. Local control and cancer-specific survival (CSS) rates were primary endpoints, and the impact of various factors on these outcomes was statistically analyzed.

RESULTS

This review of 522 patients includes 24 with Tis, 356 with T1, and 142 with T2. Ultimate local control rates were as follows: Tis 87.5%, T1 94.7%, and T2 84.5%. Multivariate analysis found fitness for surgery, no involvement of anterior commissure, normal cord movement, and radiotherapy dose >60 Gy significant for local control. Fitness for surgery, no involvement of the anterior commissure, normal cord movement, and no ventricular involvement were significant prognostic factors for CSS.

CONCLUSION

Definitive radiotherapy for early glottic carcinoma provides high local control rates, with the option of surgical salvage to achieve ultimate local control.

摘要

背景

早期声门型癌采用放射治疗有很高的局部控制率。本研究评估了单中心的经验。

方法

对 1967 年至 2006 年期间在威尔斯亲王医院因Tis/T1/T2/N0 期早期声门型癌接受根治性放射治疗的所有患者进行回顾性分析。局部控制率和癌症特异性生存率（CSS）是主要终点，统计分析了各种因素对这些结果的影响。

结果

本研究共纳入 522 例患者，其中Tis 期 24 例，T1 期 356 例，T2 期 142 例。最终局部控制率如下：Tis 期为 87.5%，T1 期为 94.7%，T2 期为 84.5%。多因素分析发现适合手术、前联合无累及、声带运动正常和放射治疗剂量>60Gy 与局部控制相关。适合手术、前联合无累及、声带运动正常和无室带累及是 CSS 的显著预后因素。